Enantioselective [1,2]-Stevens rearrangement using sugar-derived alkoxides as chiral promoters

The first example of enantioselective base-induced [1,2]Stevens rearrangement was achieved by using the newly developed D-glucose-derived lithium alkoxide as a chiral promoter. This rearrangement provides an alpha-amino ketone having a pseudoquaternary chiral center in an enantioenriched form.