期刊
SYNAPSE
卷 65, 期 11, 页码 1119-1127出版社
WILEY-BLACKWELL
DOI: 10.1002/syn.20946
关键词
PET; positron emission tomography; serotonin; 5-HT1B receptor; fenfluramine; endogenous competition
资金
- GlaxoSmithKline
- Division of Translational Imaging, Department of Psychiatry, Columbia University
[C-11] P943 is a recently developed PET radiotracer for serotonin 5-HT1B receptors. We characterized a number of its in vivo pharmacokinetic properties, including the evaluation of its two stereo-isomers, saturability of specific binding, selectivity for 5-HT1B and 5-HT1D receptors, and vulnerability to pharmacologically induced increases in endogenous 5-HT levels. Six isoflurane-anesthetized baboons were scanned with [C-11] P943 at baseline, and following various pharmacological manipulations. The interventions included the administration of pharmacological doses of P943, SB-616234-S (a 5-HT1B selective antagonist), SB-714786 (a 5-HT1D selective antagonist), as well as the administration of 5-HT releasing agents (fenfluramine, amphetamine) and 5-HT reuptake inhibitor (citalopram). [C-11] P943 was observed to bind saturably and specifically to 5-HT1B receptors and to be sensitive to all three challenges known to alter 5-HT levels in the proximity of receptors. [C-11] P943 shows promise as a tracer to image serotonin function in healthy subjects as well as subjects with psychiatric or neurologic conditions. Synapse 65:1119-1127, 2011. (C) 2011 Wiley-Liss, Inc.
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