期刊
SWISS MEDICAL WEEKLY
卷 143, 期 -, 页码 -出版社
E M H SWISS MEDICAL PUBLISHERS LTD
DOI: 10.4414/smw.2013.13758
关键词
nanomaterials; lung cell-interaction; lung models; in vitro; epithelial airway barrier; endocytosis; risk assessment
资金
- Swiss National Foundation [NRP64, 320030_138365/1, PP00P2_123373]
- German Research Foundation [SPP1313]
- Lunge Zurich
- Adolphe Merkle Foundation
- FriMat
- University of Fribourg
- Swiss National Science Foundation (SNF) [PP00P2_123373, 320030_138365] Funding Source: Swiss National Science Foundation (SNF)
Due to the constant expansion within the nanotechnology industry in the last decade, nanomaterials are omnipresent in society today. Nanotechnology-based products have numerous different applications ranging from electronic (e. g., advanced memory chips) to industrial (e. g., coatings or composites) to biomedical (e. g., drug delivery systems, diagnostics). Although these new nanomaterials can be found in many everyday products, their effects on the human body have still to be investigated in order to identify not only their risk, but also their potential benefits towards human health. Since the lung is commonly thought to be the main portal of entry into the human body for nanomaterials released within the environment, this review will attempt to summarise the current knowledge and understanding of how nanomaterials interact with the respiratory tract. Furthermore, the advantages and disadvantages of different experimental model systems that are commonly used to study this exposure route to the human body will be discussed.
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