期刊
SWISS MEDICAL WEEKLY
卷 142, 期 -, 页码 -出版社
E M H SWISS MEDICAL PUBLISHERS LTD
DOI: 10.4414/smw.2012.13548
关键词
liver regeneration; serotonin; partial hepatectomy
Serotonin has a multifunctional role in many different organs serving either as a neurotransmitter in the central nervous system or a paracrine factor in the gastrointestinal tract. Over 90% of serotonin is synthesised in the enterochromaffin cells of the intestine and subsequently taken up by platelets. The involvement of platelet-derived serotonin in liver mass restoration after partial hepatectomy or toxic injury has been greatly investigated during the last decade. There is a growing body of evidence implicating serotonin in hepatic regeneration through altered expression of serotonin receptor subtypes in the liver. This review article provides a brief overview on the current knowledge about the actions of serotonin in liver regeneration.
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