期刊
SURVEY OF OPHTHALMOLOGY
卷 53, 期 1, 页码 16-40出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2007.10.010
关键词
autosomal dominant neovascular inflammatory vitreoretinopathy congenital stationary night blindness; Duchenne-Becker muscular dystrophy; infantile Refsum disease, juvenile Batten disease; juvenile retinoschisis; melanoma-associated retinopathy; methonal intoxication; Muller cell sheen dystrophy; negative ERG; ocular siderosis; quinine; retinal ischemia; vigabatrin; snowflake vitreoretinal degeneration
Inner retinal dysfunction is encountered in a number of retinal disorders, either inherited or acquired, as a primary or predominant defect. Fundus examination is rarely diagnostic in these disorders, although some show characteristic features, and careful electrophysiological assessment of retinal function is needed for accurate diagnosis. The ERG in inner retinal dysfunction typically shows a negative waveform with a preserved a-wave and a selectively reduced b-wave. Advances in retinal physiology and molecular genetics have led to a greater understanding of the pathogenesis of these disorders. This review summarizes current knowledge on normal retinal physiology, the investigative techniques used and the range of clinical disorders in which there is predominantly inner retinal dysfunction.
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