期刊
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
卷 22, 期 4, 页码 641-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2013.06.008
关键词
PI3K/Akt/mTOR signaling pathway; PTEN; Cell signaling; Molecular targeted therapy
资金
- National Cancer Institute [T32 CA009599-23, 5R21 CA159270]
- Susan G. Komen for the Cure [SAC10006]
- Stand Up to Cancer Dream Team Translational Research Grant
- Program of the Entertainment Industry Foundation [SU2C-AACR-DT0209]
- Kleberg Center for Molecular Markers at The University of Texas MD Anderson Cancer Center
- National Center for Research Resources [3UL1RR024148, UL1TR000371]
This article presents an overview of the PI3K/Akt/mTOR signaling pathway. As a central regulator of cell growth, protein translation, survival, and metabolism, activation of this signaling pathway contributes to the pathogenesis of many tumor types. Biochemical and genetic aberrations of this pathway observed in various cancer types are explored. Last, pathway inhibitors both in development and already approved by the Food and Drug Administration are discussed.
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