期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 10, 期 1, 页码 113-127出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474124.2016.1104246
关键词
Biliary tree; cholangiocarcinoma; intraductal papillary neoplasm; intraductal tubular neoplasm of bile duct; intraepithelial biliary neoplasia; intraepithelial spread; mucinous cystic neoplasm; peribiliary glands
Cholangiocarcinomas (CCAs) are anatomically classified into intrahepatic, perihilar, and distal types. The gross pathological classification of intrahepatic CCAs divides them into mass-forming, periductal-infiltrating, and intraductal-growth types; and perihilar/distal CCAs into flat- and nodular-infiltrating and papillary types. Unique preinvasive lesions appear to precede individual gross types of CCA. Biliary intraepithelial neoplasia, a flat lesion, precedes periductal-, flat-, and nodular-infiltrating CCAs, whereas intraductal papillary neoplasm of the bile duct (IPNB) precedes the intraductal-growth and papillary type of CCAs. IPNBs are heterogeneous in their histological and pathological profiles along the biliary tree. Hepatobiliary cystadenomas/adenocarcinomas are reclassified as cystic IPNBs and hepatic mucinous cystic neoplasms. Peribiliary glands may participate in the development of CCAs. These latest findings present a new challenge for understanding the pathology of CCAs.
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