期刊
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
卷 23, 期 9, 页码 922-930出版社
OXFORD UNIV PRESS
DOI: 10.1177/2047487315624524
关键词
Epidemiology; nutrition; arrhythmias; clinical electrophysiology; drugs
资金
- National Heart, Lung, and Blood Institute [HL-115623]
- European Research Council (ERC)
- EU [281760]
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (National Center for Research Resources, National Institutes of Health) [KL2 TR001100]
- Danish Cancer Society
- Danish Council for Strategic Research (Aalborg AF-Study Group)
- Harvard Catalyst \ The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [KL2 TR001100]
Background There have been discrepant findings on whether coffee consumption is associated with the rate of developing atrial fibrillation (AF). Methods and results We used data on 57,053 participants (27,178 men and 29,875 women) aged 50-64 years in the Danish Diet, Cancer and Health study. All participants provided information on coffee intake via food-frequency questionnaires at baseline. Incident AF was identified using nationwide registries. During a median follow-up of 13.5 years, 3415 AF events occurred. Compared with no intake, coffee consumption was inversely associated with AF incidence, with multivariable-adjusted hazard ratios of 0.93 (95% confidence interval [CI] 0.74-1.15) for more than none to <1 cup/day, 0.88 (95% CI 0.71-1.10) for 1 cup/day, 0.86 (95% CI 0.71-1.04) for 2-3 cups/day, 0.84 (95% CI 0.69-1.02) for 4-5 cups/day, 0.79 (95% CI 0.64-0.98) for 6-7 cups/day and 0.79 (95% CI 0.63-1.00) for >7 cups/day (p-linear trend=0.02). Conclusions In this large population-based cohort study, higher levels of coffee consumption were associated with a lower rate of incident AF.
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