期刊
SURGERY FOR OBESITY AND RELATED DISEASES
卷 10, 期 6, 页码 1188-1195出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.soard.2014.06.005
关键词
Functional MRI; Bariatric surgery; Neural mechanisms; Weight loss; Neuroimaging; Baseline predictor
类别
资金
- University of Missouri research board
Background: Recent research suggests that preintervention functional magnetic resonance imaging (fMRI) data may predict weight loss outcomes among patients who participate in a behavioral weight loss plan. No study has examined whether presurgical brain activation can predict outcomes following bariatric surgery. Method: The aim of the present study was to determine if brain activations during a presurgical fMRI food-motivation paradigm are associated with weight loss 3 and 6 months following laparoscopic adjustable gastric banding (LAGB). Nineteen participants viewed food and nonfood pictures from a well-established food motivation paradigm during an fMRI scanning session before LAGB surgery. Weight was assessed presurgery and 3 and 6 months postsurgery; data for all participants was available at each time point. fMRI data were analyzed using the BrainVoyager QX statistical package. Whole brain voxelwise correlations of presurgery (food-nonfood) brain activation and weight, corrected for multiple comparisons, were performed to analyze the relationship between presurgical brain activation and subsequent weight loss. The settings were a medical university brain imaging center and 2 surgical weight loss centers in a major metropolitan area. Results: Increased activity in frontal regions associated with cognitive control (medial, middle, superior frontal gyms) and posterior cingulate cortex was associated with weight loss following LAGB. Conclusion: We found that neural activity in previously established regions associated-with cognitive and behavioral self-regulation predicts weight loss following bariatric surgery. These preliminary findings highlight the role of neural circuitry in the success and maintenance of weight loss and suggest a possible future use of fMRI in screening LAGB surgery candidates. (C) 2014 American Society for Metabolic and Bariatric Surgery. All rights reserved.
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