Solid-phase Pd-catalysed cross-coupling methods for the construction of p-conjugated peptide nanomaterials

We describe the development of two procedures for the synthesis of peptides that are embedded with a variety of -conjugated semi-conducting oligomers. These procedures utilise solid-phase variants of classical palladium-catalysed cross-couplings commonly used to prepare -conjugated oligomers. The resulting peptide--electron hybrids are soluble in aqueous media and self-assemble to produce 1D nanostructures, simultaneously forming networks of -stacked conduits. The procedures have allowed for the inclusion of complex chromophores including mixed aryl units, ethynylene linkers and sexithiophenes where the latter peptide's nanostructures demonstrated substantial conductivity when employed as an active layer in a field-effect transistor.