期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 16, 期 -, 页码 93-100出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2015.05.004
关键词
Adolescent; Treatment outcome; Marijuana; fMRI; Antisaccade; Reward
资金
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse [R01 AA014357, R21 AA016272, R21 AA017128, K02 AA018195]
This preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS) task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and generally improves with reward cues. We hypothesized that when preparing to execute an AS, greater activation in regions associated with cognitive and oculomotor control supporting AS, particularly during reward cue trials, would be associated with lower substance use severity at 6-month follow-up. Adolescents (n = 14, ages 14-18) recruited from community-based outpatient treatment completed an fMRI reward cue AS task (reward and neutral conditions), and provided follow-up data. Results indicated that AS errors decreased in reward, compared to neutral, trials. AS behavioral performance, however, was not associated with treatment outcome. As hypothesized, activation in regions of interest (ROIs) associated with cognitive (e.g., ventrolateral prefrontal cortex) and oculomotor control (e.g., supplementary eye field) during reward trials were inversely correlated with marijuana problem severity at 6-months. ROI activation during neutral trials was not associated with outcomes. Results support the role of motivational (reward cue) factors to enhance cognitive control processes, and suggest a potential brain-based correlate of youth treatment outcome. (C) 2015 The Authors. Published by Elsevier Ltd.
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