期刊
CURRENT STEM CELL RESEARCH & THERAPY
卷 10, 期 3, 页码 245-250出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X09666140812112305
关键词
Cytokines; gastrointestinal cancer; inflammation; iPSCs; tumor microenvironment
资金
- Career Development and Support Fellowship Future Research Leader Grant of the NSW Cancer Institute [08/FRL/1-04]
- Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney
- National Health and Medical Research Council of Australia (NHMRC) [APP1047417]
- Cancer Council NSW [APP1070076]
Connections between inflammation and cancer are a rapidly developing field. Some gastrointestinal tract cancers arise from infection, chronic irritation, and ensuing inflammation. Cellular effectors and mediators are important constituents of the tumor microenvironment, including neoplastic, stromal, and migratory hematopoietic cells. Complex interaction between these cells in the tumor microenvironment regulates tumor growth, progression, metastasis, and angiogenesis. Tumor-associated macrophages represent the major inflammatory cell population in tumors, which orchestrate various aspects of cancer. Cytokines and chemokines are major mediators of communication between cells in the tumor microenvironment. The concept of oncogene builds up an inflammatory pre-neoplastic microenvironment has emerged in the last few years. On the other hand, the development of induced pluripotent stem cells (iPSCs) unraveled a mystery in stem cell research. However, there are still some debates about iPSCs which should be answered by science.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据