期刊
CURRENT OPINION IN VIROLOGY
卷 15, 期 -, 页码 112-118出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.10.003
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资金
- Centers for Disease Control and Prevention Grant [1RO1AI069217-01]
- National Institute of Allergy and Infectious Diseases [NO1-AI-25490, R01-AI-077669]
- National Science Foundation, National Science Foundation National Institutes of Health Ecology of Infectious Disease program, National Institutes of Health (NIH) [EF-0914866]
- Foundation for Research (Carson City, NV)
- North Carolina Agricultural Research Service
- National Institute of Allergy and Infectious Disease, National Institutes of Health [T32-AI055429-03]
The inter-relationship between mosquitoes and the viruses they transmit is complex. While previously understood barriers to infection and transmission remain valid, additional factors have been uncovered that suggest an 'arms race' between mosquito and virus. These include the mosquito microbiota and interplay between mosquito and viral genetics. Following an infectious blood meal, the mosquito mounts an immune and transcriptional response, leading to altered expression of multiple genes. These complex interactions, specific to vector and virus genotypes, combine with external influences, particularly temperature, to determine vector competence. The mosquito's response to the infecting agent may have consequences in terms of longevity, feeding behavior and/or fecundity. These factors, together with population density and the frequency of host contact determine vectorial capacity.
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