期刊
STRUCTURE
卷 21, 期 9, 页码 1509-1521出版社
CELL PRESS
DOI: 10.1016/j.str.2013.06.002
关键词
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资金
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Hungarian National Science Foundation [OTKA K83314]
- EU [TAMOP-4.2.2/B-10/1-2010-0013]
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
The cellular network is highly interconnected. Pathways merge and diverge. They proceed through shared proteins and may change directions. How are cellular pathways controlled and their directions decided, coded, and read? These questions become particularly acute when we consider that a small number of pathways, such as signaling pathways that regulate cell fates, cell proliferation, and cell death in development, are extensively exploited. This review focuses on these signaling questions from the structural standpoint and discusses the literature in this light. All co-occurring allosteric events (including posttranslational modifications, pathogen binding, and gain-of-function mutations) collectively tag the protein functional site with a unique barcode. The barcode shape is read by an interacting molecule, which transmits the signal. A conformational barcode provides an intracellular address label, which selectively favors binding to one partner and quenches binding to others, and, in this way, determines the pathway direction, and, eventually, the cell's response and fate.
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