期刊
CELL REPORTS
卷 13, 期 11, 页码 2456-2469出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.11.025
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资金
- Cancer Research UK [15681, 15154, 14257] Funding Source: researchfish
- The Francis Crick Institute [10144, 10095, 10009, 10112, C50839/A18100, 10002, 2013NovPR182, 10096] Funding Source: researchfish
- Worldwide Cancer Research [15-0273] Funding Source: researchfish
- Worldwide Cancer Research [15-0273] Funding Source: Medline
- Breast Cancer Now [2013NOVPR182] Funding Source: Medline
During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood. Here, we found that metastatic initiating cells (MICs) exhibit a high capacity for lung fibroblast activation as a result of Thrombospondin 2 (THBS2) expression. Importantly, inhibiting the mesenchymal phenotype of MICs by blocking the epithelial-to-mesenchymal transition (EMT)-associated kinase AXL reduces THBS2 secretion, niche-activating ability, and, consequently, metastatic competence. Subsequently, disseminated metastatic cells revert to an AXL-negative, more epithelial phenotype to proliferate and decrease the phosphorylation levels of TGF-beta-dependent SMAD2-3 in favor of BMP/SMAD1-5 signaling. Remarkably, newly activated fibroblasts promote this transition. In summary, our data reveal a crosstalk between cancer cells and their microenvironment whereby the EMT status initially triggers and then is regulated by niche activation during metastatic colonization.
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