期刊
CELL REPORTS
卷 13, 期 1, 页码 122-131出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.08.063
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资金
- Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries, and Food Industry
- Program for Promotion of Basic and Applied Research for Innovations in Bio-oriented Industry
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Ministry of Health and Welfare of Japan
- JST-Precursory Research for Embryonic Science and Technology (PRESTO) program
- JST-Core Research for Evolutional Science and Technology (CREST) program
- JST-Exploratory Research for Advanced Technology (ERATO) program
- Kishimoto Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [15K18950, 26670241, 26293111, 15K19142, 26111006] Funding Source: KAKEN
Bioenergetic metabolism varies during cell differentiation, but details of B cell metabolism remain unclear. Here, we show the metabolic changes during B cell differentiation in the intestine, where B cells differentiate into IgA(+) plasma cells (PCs). Naive B cells in the Peyer's patches (PPs) and IgA(+) PCs in the intestinal lamina propria (iLP) both used the tricarboxylic acid (TCA) cycle, but only IgA(+) PCs underwent glycolysis. These metabolic differences reflected their dependencies on vitamin B-1, an essential cofactor for the TCA cycle. Indeed, the diminished activity of the TCA cycle after dietary vitamin B1 depletion decreased the number of naive B cells in PPs without affecting IgA(+) PCs in the iLP. The maintenance of naive B cells by dietary vitamin B1 was required to induce-but not maintain-intestinal IgA responses against oral antigens. These findings reveal the diet-mediated maintenance of B cell immunometabolism in organized and diffuse intestinal tissues.
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