期刊
STRUCTURAL CHEMISTRY
卷 21, 期 5, 页码 1117-1129出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11224-010-9654-2
关键词
Molecular mechanisms; Protein crystallography; Protein structure-function; Rational drug design
资金
- Australian Research Council, Griffith University
- James N Kirby Foundation
- National Health and Medical Research Council
- Rebecca L Cooper Foundation
- Griffith University
- Queensland State Government's Department of Employment, Economic Development and Innovation
- Agilent Foundation
- Prostate Cancer foundation of Australia
This review introduces the Structural Chemistry Program at Griffith University's Eskitis Institute, and provides a brief overview over its current and future research portfolio. Capitalising on the co-location with the Queensland Compound Library (QCL), Australia's only small molecule repository, our laboratory investigates the structure and function of proteins with the aim of learning about their molecular mechanisms. Consequently, these studies also feed into drug discovery and design. The thematic focus of our Program is on proteins involved in infection, inflammation and neurological diseases, and this review highlights a few of our recent research efforts in this area.
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