期刊
CELL REPORTS
卷 13, 期 2, 页码 399-411出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.08.078
关键词
-
类别
资金
- German Research foundation (DFG) [DU1172/2, 14681, DU1172/3, 1394]
- Technische Universitat Dresden
- Russian Science Foundation [14-50-00060]
- DFG [NE1466/2-1]
- German Research foundation [DU548/2-1, SFB643-TPA7]
- BayGene
- Russian Science Foundation [14-50-00060] Funding Source: Russian Science Foundation
Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood. Using Mcpt5-CreTNF(FL/FL) mice, we show here that the absence of TNF exclusively in mast cells impaired the expansion of CD8(+) T cells upon sensitization and the T-cell-driven adaptive immune response to elicitation. T cells primed in the absence of mast cell TNF exhibited a diminished efficiency to transfer sensitization to naive recipients. Specifically, mast cell TNF promotes CD8(+) dendritic cell (DC) maturation and migration to draining lymph nodes. The peripherally released mast cell TNF further critically boosts the CD8(+) T-cell-priming efficiency of CDS' DCs, thereby linking mast cell effects on T cells to DC modulation. Collectively, our findings identify the distinct potential of mast cell TNF to amplify CD8(+) DC functionality and CD8(+) T-cell-dominated adaptive immunity, which may be of great importance for immunotherapy and vaccination approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据