期刊
CELL REPORTS
卷 10, 期 1, 页码 75-87出版社
CELL PRESS
DOI: 10.1016/j.celrep.2014.12.005
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资金
- NINDS/NIH [NS075136]
- Klingenstein Foundation
- NIH/NIDA [DA031777]
- Stanford University Department of Anesthesiology, Perioperative and Pain Medicine
- Stanford Institute for Neuro-Innovation and Translational Neurosciences
- Foundation for Anesthesia Education and Research RFG
Changes in basal ganglia plasticity at the corticostriatal and thalamostriatal levels are required for motor learning. Endocannabinoid-dependent long-term depression (eCB-LTD) is known to be a dominant form of synaptic plasticity expressed at these glutamatergic inputs; however, whether eCB-LTD can be induced at all inputs on all striatal neurons is still debatable. Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. We found that eCB-LTD was successfully induced at corticostriatal synapses, independent of postsynaptic striatal spiny projection neuron (SPN) subtype. Conversely, eCB-LTD was only nominally present at thalamostriatal synapses. This dichotomy was attributable to the minimal expression of cannabinoid type 1 (CB1) receptors on thalamostriatal terminals. Furthermore, coactivation of dopamine receptors on SPNs during LTD induction re-established SPN-subtype-dependent eCB-LTD. Altogether, our findings lay the groundwork for understanding corticostriatal and thalamostriatal synaptic plasticity and for striatal eCB-LTD in motor learning.
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