期刊
CELL REPORTS
卷 10, 期 5, 页码 820-832出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.01.034
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资金
- PSL* Research University [ANR-10-LABX-54, ANR-11-IDEX-0001-02]
- INTERREG IV Rhin Superieur program
- European Funds for Regional Development (FEDER) [A31]
- Fondation Bettencourt Schuller
- CNRS
- NeRF Ile de France
- Ecole des Neurosciences de Paris
- Fondation pour la Recherche Medicale
- ATIP AVENIR
- Fondation Jerome Lejeune
- Association Francaise pour le Syndrome de Rett [ANR-2010-JCJC-1403-1, ANR-13-SAMA-0010-01]
Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories. What regulates the specific characteristics of each type of synapse, in terms of number, morphology, and subcellular localization, remains to be understood. Here, we show that the signaling pathway formed by the secreted complement C1Q-related protein C1QL1 and its receptor, the adhesion- GPCR brain angiogenesis inhibitor 3 (BAI3), controls the stereotyped pattern of connectivity established by excitatory afferents on cerebellar Purkinje cells. The BAI3 receptor modulates synap-togenesis of both parallel fiber and climbing fiber afferents. The restricted and timely expression of its ligand C1QL1 in inferior olivary neurons ensures the establishment of the proper synaptic territory for climbing fibers. Given the broad expression of C1QL and BAI proteins in the developing mouse brain, our study reveals a general mechanism contributing to the formation of a functional brain.
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