期刊
STROKE
卷 44, 期 7, 页码 2004-+出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.113.001187
关键词
acute stroke; hematoma; intracerebral hemorrhage; serum calcium; stroke outcome
资金
- Ministry of Health, Labor and Welfare, Japan [H23-Junkanki-Ippan-010, H24-Junkanki-Ippan-011]
- Intramural Research Fund for Cardiovascular Diseases from the National Cerebral and Cardiovascular Center [H22-4-1, H23-4-3]
Background and Purpose-We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. Methods-A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based on admission serum calcium levels (Q1 [<= 9.0], Q2 [9.1-9.3], Q3 [9.4-9.7], Q4 [>= 9.8] mg/dL). Results-Median hematoma volumes for each quartile (Q1 to Q4) were 18, 9, 10, and 9 mL (P=0.005), and median National Institutes of Health Stroke Scale scores were 16, 11, 11, and 9 (P=0.010), respectively. On multivariate analysis, Q1 had larger hematoma volume (P=0.025) and higher National Institutes of Health Stroke Scale score (P=0.020) than Q4. There were fewer patients with modified Rankin Scale scores 0 to 2 in Q1 than Q4 after adjustment for risk factors and comorbidities (odds ratio, 0.31; 95% confidence interval, 0.11-0.84) but not after additional adjustment for hematoma volume and National Institutes of Health Stroke Scale score. There were more patients with modified Rankin Scale scores 5 to 6 (P=0.016) and with fatal outcomes (P=0.048) in Q1 than Q4 as crude values, but not after adjustment. Conclusions-Low admission serum calcium levels were associated with larger hematoma volume and higher National Institutes of Health Stroke Scale score among patients with acute intracerebral hemorrhage.
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