期刊
STROKE
卷 43, 期 10, 页码 2689-+出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.112.654954
关键词
acute ischemic stroke; atrial fibrillation; ECG; Holter ECG; stroke unit; transient ischemic attack
资金
- Bayer
- Boehringer Ingelheim
- Phototera
- JohnsonJohnson
- Else Kroner Memorial Scholarship
- Sanofi-Aventis
- Ferrer
- Paion
- 3M Medica
- MEDA Pharma
- AstraZeneca
- Bayer Healthcare
- Daicchi-Sankyo
- Medtronic
- Merck
- MSD
- Otsuka Pharma
- Pfizer/BMS
- Servier
- Siemens
- TAKEDA
- Cardiovascular Therapeutics
- OMRON
- St Jude Medical
Background and Purpose-Cardioembolism in paroxysmal atrial fibrillation (pxAF) is a frequent cause of ischemic stroke. Sensitive detection of pxAF after stroke is crucial for adequate secondary stroke prevention; the optimal diagnostic modality to detect pxAF on stroke units is unknown. We compared 24-hour Holter electrocardiography (ECG) with continuous stroke unit ECG monitoring (CEM) for pxAF detection. Methods-Patients with acute ischemic stroke or transient ischemic attack were prospectively enrolled. After a 12-channel ECG on admission, all patients received 24-hour Holter ECG and CEM. Additionally, ECG monitoring data underwent automated analysis using dedicated software to identify pxAF. Patients with a history of atrial fibrillation or with atrial fibrillation on the admission ECG were excluded. Results-Four hundred ninety-six patients (median age, 69 years; 61.5% male) fulfilled all inclusion criteria (ischemic stroke: 80.4%; transient ischemic attack: 19.6%). Median stroke unit stay lasted 88.8 hours (interquartile range, 65.0-122.0). ECG data for automated CEM analysis were available for a median time of 64.0 hours (43.0-89.8). Paroxysmal AF was documented in 41 of 496 patients (8.3%). Of these, Holter detected pxAF in 34.1%; CEM in 65.9%; and automated CEM in 92.7%. CEM and automated CEM detected significantly more patients with pxAF than Holter (P<0.001), and automated CEM detected more patients than CEM (P<0.001). Conclusions-Automated analysis of CEM improves pxAF detection in patients with stroke on stroke units compared with 24-hour Holter ECG. The comparative usefulness of prolonged or repetitive Holter ECG recordings requires further evaluation. (Stroke. 2012;43:2689-2694.)
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