期刊
STROKE
卷 43, 期 1, 页码 256-U509出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.111.632208
关键词
endothelial progenitor cells; hypertension; leukoaraiosis; T-lymphocytes; white matter lesions
资金
- Netherlands Heart Foundation [2005B022]
- Novartis Foundation for Cardiovascular Excellence [003/07]
Background and Purpose-Cerebral small vessel disease (CSVD) may be caused by endothelial dysfunction, whereas endothelial progenitor cells (EPC) may attenuate endothelial dysfunction. Their vitality is lower in CSVD. A subset of lymphocytes, angiogenic T-cells, is capable to stimulate EPC function. The purpose of our study was to explore the relation between CSVD manifestations, angiogenic T-cells, and EPC in hypertensive patients with CSVD. Methods-We compared 32 essential hypertensive patients with CSVD (white matter lesions, asymptomatic lacunar infarcts, or microbleeds on 1.5-Tesla MRI) to 29 age-matched and sex-matched hypertensive controls. We counted angiogenic T-cells (CD3(+)/CD31(+)/CD184(+)) and putative EPC (CD31(+)/CD34(+)/CD45(-)/KDR(+)) by flow cytometry and determined EPC vitality by in vitro cluster formation. Results-Putative EPC numbers were lower in hypertensive individuals with CSVD than in those without (10 +/- 7.10(3)/mL versus 13 +/- 6.10(3)/mL [median +/- interquartile range]; P=0.011). Angiogenic T-cell numbers were also lower in hypertensive individuals with CSVD than in those without (0.56 +/- 0.25.10(9)/mL versus 0.78 +/- 0.50.10(9)/mL; P=0.008). Higher angiogenic T-cell numbers independently related to absence of CSVD (odds ratio, 0.088; 95% confidence interval, 0.012-0.627). Conclusions-Our data suggest that angiogenic T-cells and putative EPC independently relate to radiological CSVD manifestations in hypertensive patients. (Stroke. 2012;43:256-258.)
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