期刊
CELL REPORTS
卷 13, 期 6, 页码 1125-1136出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.09.082
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资金
- ETH
- Swiss National Science Foundation [310030-113947, 310030_146140]
- Swiss National Science Foundation (SNF) [310030_146140] Funding Source: Swiss National Science Foundation (SNF)
Tissue-resident memory T cells (T-RM) reside in barrier tissues and provide local immediate protective immunity. Here, we show that the salivary gland (SG) most-effectively induces CD8(+) and CD4(+) T-RM cells against murine cytomegalovirus (MCMV), which persists in and spreads from this organ. T-RM generation depended on local antigen for CD4(+), but not CD8(+), T-RM cells, highlighting major differences in T cell subset-specific demands for T-RM development. CMV-specific CD8(+) T cells fail to control virus replication upon primary infection in the SG due to CMV-induced MHC I downregulation in glandular epithelial cells. Using intraglandular infection, we challenge this notion and demonstrate that memory CD8(+) T cells confer immediate protection against locally introduced MCMV despite active viral immune evasion, owing to early viral tropism to cells that largely withstand MHC I downregulation. Thus, we unravel a yet-unappreciated role for memory CD8(+) T cells in protecting mucosal tissues against CMV infection.
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