期刊
CELL REPORTS
卷 13, 期 2, 页码 315-325出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.09.001
关键词
-
类别
资金
- Edward Mallinckrodt, Jr. Foundation
- David and Lucile Packard Foundation
- NICHD, NIH [R01HD065816]
- Johns Hopkins University
- Howard Hughes Medical Institute
- Deutsche Forschungsgemeinschaft [SCHI 871/2, SCHI 871/5, SCHI 871/6, GR 1748/6, INST 39/900-1]
- DFG [SFB850]
- European Research Council [ERC-2011-StG 282111-ProteaSys]
- Excellence Initiative of the German Federal Government [EXC 294]
- Excellence Initiative of the German State Government [EXC 294]
Extrinsic cues from the niche are known to regulate adult stem cell self-renewal versus differentiation. Here, we report that an aminopeptidase Slamdance (Sda) acts in the Drosophila testicular niche to maintain germline stem cells (GSCs) and regulate progenitor germ cell dedifferentiation. Mutations in sda lead to dramatic testicular niche deterioration and stem cell loss. Recombinant Sda has specific aminopeptidase activity in vitro, and the in vivo function of Sda requires an intact aminopeptidase domain. Sda is required for accumulation of mature DE-cadherin, and overexpression of DE-cadherin rescues most sda mutant phenotypes, suggesting that DE-cadherin is an important target of Sda. Finally, Sda is both necessary and sufficient to promote dedifferentiation during aging and recovery from genetically manipulated depletion of GSCs. Together, our results suggest that a niche factor promotes both stem cell maintenance and progenitor cell dedifferentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据