期刊
STROKE
卷 41, 期 10, 页码 S72-S74出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.110.595371
关键词
stroke; hypothermia; neuroprotection
资金
- NINDS NIH HHS [R01 NS040516, P50 NS014543, R01 NS40516, NS014543] Funding Source: Medline
Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experiencing hypoxic brain insults. Its role, however, in stroke therapy has yet to be established. Translating preclinical data to the clinical arena presents unique challenges with regard to cooling in patients who are generally awake and may require additional therapies, such as reperfusion. We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy. (Stroke. 2010;41[suppl 1]:S72-S74.)
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