期刊
STROKE
卷 41, 期 3, 页码 437-442出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.109.563502
关键词
white matter disease; leukoaraiosis; hyperlipidemia; risk factors
资金
- Bugher Foundation-American Stroke Association
- National Institute of Neurological Disorders and Stroke [5P50NS051343, R01 NS04217]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [K23NS42720]
- Deane Institute for Integrative Study of Atrial Fibrillation and Stroke
- Ministerio de Sanidad y Consumo de EspaPa
- Instituto de Salud Carlos III [PI051737, CM06100067, RD06/0009]
Background and Purpose-White matter hyperintensity (WMH), or leukoaraiosis, is a radiologic finding generally assumed to reflect diseased small cerebral vasculature. WMH has significant functional impact through its relation to cognitive decline and risk of ischemic and hemorrhagic stroke. Accumulating evidence suggests that some manifestations of small-vessel disease such as intracerebral hemorrhage are associated with low levels of cholesterol. We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS). Methods-We analyzed 2 independent, hospital-based AIS cohorts. Demographic and clinical data were collected prospectively. WMH was measured using semiautomated volumetric image analysis and a semiquantitative visual grading scale. Univariate and multivariable regression analyses were used to assess the relation between WMH severity and study variables. Results-A total of 631 and 504 subjects in the first and second cohorts, respectively, were included. In univariate analyses, advancing age and hypertension were associated with severity of WMH (P < 0.001) in both cohorts. In the multivariable analysis, after controlling for age, sex, and significant risk factors in the univariate and age-adjusted analyses, patients with a history of hyperlipidemia had less severe WMH in both cohorts (P < 0.01). Conclusions-Results from 2 independent cohorts demonstrate that AIS patients with a history of hyperlipidemia have less severe WMH at the time of stroke. These data support the hypothesis that hyperlipidemia may play a relatively protective role in cerebral small-vessel disease. (Stroke. 2010;41:37-442.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据