期刊
STROKE
卷 40, 期 3, 页码 S88-S89出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.108.533281
关键词
angiogenesis; cerebral hemorrhage; neurogenesis; plasticity; thrombin
资金
- National Institutes of Health [NS-017760, NS-039866, NS-047245]
- American Heart Association [0755717Z, 0840016N]
Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema, and neuronal death after ICH, our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis, and plasticity may facilitate brain recovery after ICH. (Stroke. 2009; 40[suppl 1]: S88-S89.)
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