期刊
STEROIDS
卷 85, 期 -, 页码 58-64出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2014.04.007
关键词
Anticancer activity; Brassinosteroids; Organic synthesis; Molecular docking; Receptor kinase BRI1; Plant bioassays
资金
- Navrat for Research, Development, and Innovations - Ministry of Education, Youth and Sports of the Czech Republic [LK21306]
- project of the Ministry of Education, Youth and Sports CR NPUI [LO1204]
- Czech Science Foundation [GACR 14-27669P]
- Student Project of Palacky University [PrF_2013_028]
- Operational Program Research and Development for Innovations - European Regional Development Fund [CZ.1.05/2.1.00/03.0058]
Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard. (C) 2014 Elsevier Inc. All rights reserved.
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