期刊
STEROIDS
卷 78, 期 14, 页码 1312-1324出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2013.10.001
关键词
Microbial transformation; 17 alpha-Ethynyl substituted steroidal drugs; Microbial strains; Cell suspension cultures
资金
- Fundamental Research Grant Scheme (FRGS), KPT, Malaysia [600-RMI/FRGS 5/3]
Structural modification of steroids through whole-cell biocatalysis is an invaluable procedure for the production of active pharmaceutical ingredients (APIs) and key intermediates. Modifications could be carried out with regio- and stereospecificity at positions hardly available for chemical agents. Much attention has been focused recently on the biotransformation of 17 alpha-ethynyl substituted steroidal drugs using fungi, bacteria and plant cell cultures in order to obtained novel biologically active compounds with diverse structure features. Present article includes studies on biotransformation on 17 alpha-ethynyl substituted steroidal drugs using microorganisms and plant cell cultures. Various experimental and structural elucidation methods used in biotransformational processes are also highlighted. (C) 2013 Elsevier Inc. All rights reserved.
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