期刊
STEROIDS
卷 78, 期 4, 页码 396-400出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.12.012
关键词
Soft coral; Nephthea sp; Cholesta-1,4-dien-3-one; Mosher's analysis; Cytotoxicity
资金
- National Natural Science Funding of China [21172094]
- Guangdong Technology Project Funding [2011A08050407]
- Tianhe Technology Project Funding [2006Z3-E4041]
- Biotechnology Research Institute at the Hong Kong University of Science and Technology
Five new steroids, (12 beta, 22R)-12-acetoxy-22-hydroxy-cholesta-1,4-dien-3-one (1), (12 beta, 22R)-12-hydroxy-22-acetoxy-cholesta-1, 4-dien-3-one (2), (12 beta, 22R)-12, 22-diacetoxy-cholesta-1, 4-dien-3-one (3), (22R)-18, 22-diacetoxy-cholesta-1, 4-dien-3-one (4), (20R, 22R)-20-hydroxy-22-acetoxy-cholesta-1, 4-dien-3-one (5), and one known steroid astrogorgol N (6), were isolated from soft coral Nephthea sp. Their structures were established by spectroscopic analysis (1D, 2D NMR, HRMS) and comparisons of their spectral data with those of related steroids. The absolute configuration at C-22 of 1 was determined to be R by Mosher's analysis. All isolated compounds exhibited cytotoxic activity against HeLa cells with IC50 values ranged from 7.51 +/- 0.22 to 18.72 +/- 0.78 mu g/mL. (C) 2013 Elsevier Inc. All rights reserved.
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