期刊
STEROIDS
卷 78, 期 2, 页码 203-209出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.09.012
关键词
25-OH-PPD derivatives; Amino acids; Anti-tumor activity; MTT
资金
- 11th Five-Year State Plan on Technology Major Projects [2009ZX09102-114]
- Technology Platform of Industrialization Chromatographic Preparation for Standard Extract of Traditional Chinese Medicine [2010ZX09401-304-105B]
- National Science Foundation of China [81273389]
In the current study, derivatives of 25-hydroxyprotopanaxadiol (25-OH-PPD) were prepared and their in vitro anti-tumor activities were tested on six different human tumor cell lines by standard MET assay. The results showed that combining an ester group combined with the presence of an amino acid moiety led to a 10-fold improved anti-tumor activity. Compound 1c exhibited the best anti-tumor activity in the in vitro assays. Compounds 2c, 3c, 4c, 5c, 6c and 8b showed better anti-tumor activities compared to the parent compound 25-OH-PPD. The current results may provide useful data for researching and developing new anti-cancer agents. (C) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据