期刊
STEROIDS
卷 77, 期 6, 页码 635-643出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2012.02.008
关键词
Desoxymethyltestosterone; Metabolites; Synthesis; Hepatocytes; GC-MS
资金
- World Anti-Doping Agency
- NSERC
Desoxymethyltestosterone (DMT; 17 beta-hydroxy-17 alpha-methyl-5 alpha-androst-2-ene) is a designer steroid present in hormonal supplements distributed illegally as such or in combination with other steroids, for self-administration. It figures on the list of substances prohibited in sports and its detection in athlete's urine samples is based upon the presence of the parent compound or the main urinary metabolite, which has not been characterized yet. Following its isolation from cultures of human fresh hepatocytes and S9 fractions of liver homogenates, we were able to identify this metabolite as being 17 alpha-methyl-2 beta,3 alpha,17 beta-trihydroxy-5 alpha-androstane. Other minor metabolites were also characterized. The production, isolation, NMR, mass spectral analyses and chemical synthesis are presented. (c) 2012 Elsevier Inc. All rights reserved.
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