期刊
STEROIDS
卷 76, 期 12, 页码 1389-1396出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2011.07.010
关键词
Marine sponge; Pandaros; Steroidal glycosides; Cytotoxic; Antiprotozoal; Haemolytic
资金
- UNESCO
- Boehringer Ingelheim Fonds
Six new steroidal saponins, pandarosides K-M (1-3) and their methyl esters (4-6), were isolated as minor components, after a careful chemical reinvestigation of the Caribbean sponge Pandaros acanthifolium. Their structures were established on the basis of spectroscopic analyses and comparison with the data obtained from previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides were tested on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Two pandarosides exhibited moderate to strong cytotoxic effect, while three acanthifoliosides showed strong haemolytic activity. (C) 2011 Elsevier Inc. All rights reserved.
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