期刊
STEROIDS
卷 75, 期 10, 页码 734-739出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2010.05.002
关键词
Asparagus filicinus; Liliaceae; Steroidal glycoside; Ecdysterone; Cytotoxic activity
Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC50 values ranging from 3.4 to 6.6 mu M. (C)2010 Elsevier Inc. All rights reserved.
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