期刊
STEROIDS
卷 74, 期 1, 页码 73-80出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.09.007
关键词
Eunicella cavolini; Trididemnum inarmatum; 5 alpha,8 alpha-Epidioxysterols; Structure elucidation; Antiproliferative activity
资金
- Greek State Scholarships Foundation
- University of Athens
Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5 alpha,8 alpha-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity. (C) 2008 Elsevier Inc. All rights reserved.
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