期刊
STEROIDS
卷 73, 期 3, 页码 245-251出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2007.10.006
关键词
Withania somnifera L.; ashwagandha; withasteroids; withanolides; mercaptoethanol; epoxide
2-Mercaptoethanol reacts selectively with the 5 beta,6 beta-epoxy steroids isolated from Withania somnifera substituting the epoxide by a six-membered oxyethylene-2'-thio ring whereas it failed to show such reactivity on 6 alpha,7 alpha-epoxy withasteroids. The structure of the product has been elucidated by spectroscopic methods, especially applying extensive 2D NMR methods. The anticancer activity of withaferin A was lost in the reaction product indicating that its activity is also linked to the free 5 beta,6 beta-epoxide functional group. (C) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据