期刊
STEROIDS
卷 73, 期 5, 页码 539-542出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.01.005
关键词
fused steroids; ethylenediamine; dehydropiperazine; microwave
The preparation of ring-A fused steroidal dehydropiperazine at the 3,4-position is herein described. The novel steroidal dehydropiperazines were prepared from the annulation reaction of ethylenediamine with 3-keto-4-en steroids in a one-pot reaction under microwave irradiation. The key step involves base catalysed aerial oxidation of the C-6 methylene group followed by cyclocondensation of ethylenediamine via Michael addition reaction. (C) 2008 Elsevier Inc. All rights reserved.
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