期刊
STEROIDS
卷 73, 期 14, 页码 1441-1445出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2008.07.008
关键词
Biotransformation; DHEA; Pregnenolone; Baeyer-Villiger oxidation; Steroidal lactones; Penicillium lilacinum
The Baeyer-Villiger monooxygenase (BVMO) produced by Penicillium lilacinum AM111, in contrast to other enzymes of this group known in the literature, is able to process 3 beta-hydroxy-5-ene steroid substrates. Transformation of DHEA and pregnenolone yielded, as a sole or main product, 3 beta-hydroxy-17a-oxa-D-homo-androst-5-en-17-one, a new metabolite of these substrates; pregnenolone was transformed also to testololactone. Testololactone was the only product of oxidation of androstenedione by P. lilacinum AM111. Investigations of the time evolution of reaction progress have indicated that the substrates stimulate activity of BVMO(s) of P.lilacinum AM111. (C) 2008 Elsevier Inc. All rights reserved.
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