期刊
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
卷 92, 期 4, 页码 211-217出版社
KARGER
DOI: 10.1159/000360583
关键词
Fetal transplantation; Huntington's disease; Restorative neurosurgery; Robotic-assisted neurosurgery; Stereotactic neurosurgery; Striatal primordium; Striatum
资金
- University of Florence
- Careggi University Hospital, Florence, Italy
- Ministero Istruzione Universita e Ricerca, Italy [N 2008XN9KLA]
- Ente Cassa di Risparmio, Florence, Italy [2011.1208]
Background: Restoration of functions in Huntington's disease (HD) by neurotransplantation stems from the formation of a striatum-like structure capable of establishing host connections as a result of grafted striatal neuroblast maturation. For the first time, we demonstrated some developmental steps accomplished by progenitor cells in the brain of an HD patient and analysed the molecular asset of the human primordium. Case Report: Surgery involved bilateral (two sessions) stereotactic, caudate-putaminal transplantation of whole ganglionic eminence fragments from single legally aborted fetuses. MRI showed that the tissue deposits of the left hemisphere grew and joined to constitute a single tissue mass that remodelled basal ganglia anatomy and remained stable in size over time. No evidence of graft growth was observed contralaterally. PET demonstrated increased striatal and stable cortical metabolism. Unified Huntington's Disease Rating Scale assessments demonstrated improvement of motor performances, which faded over the 36-month follow-up. Cognitive performance tended to decrease at a lower rate than before transplantation. Conclusion: The striatal primordium grew into the host brain and this process was associated with metabolic change and some clinical benefit. The study suggests the plasticity and reparative potential of un-manipulated primordium in an era where promising cellbased therapies are still in their infancy. (C) 2014 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据