期刊
STEM CELLS
卷 32, 期 9, 页码 2467-2479出版社
WILEY
DOI: 10.1002/stem.1733
关键词
Bone marrow stromal cells; Osteoblast; Adipogenesis; Osteoporosis; Differentiation; Proliferation
资金
- National Research Foundation of Korea [NRF-2013R1A2A2A01010911, NRF-2013R1A2A1A01007642]
- Oromaxillofacial Dysfunction Research Center for the Elderly at Seoul National University [2013070465]
- National Research Foundation of Korea [2013R1A2A2A01010911, 2013R1A2A1A01007642, 2008-0062281] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In bone marrow, bone marrow stromal cells (BMSCs) have the capacity to differentiate into osteoblasts and adipocytes. Age-related osteoporosis is associated with a reciprocal decrease of osteogenesis and an increase of adipogenesis in bone marrow. In this study, we demonstrate that disruption of nuclear factor I-C (NFI-C) impairs osteoblast differentiation and bone formation, and increases bone marrow adipocytes. Interestingly, NFI-C controls postnatal bone formation but does not influence prenatal bone development. We also found decreased NFI-C expression in osteogenic cells from human osteoporotic patients. Notably, transplantation of Nfic-overexpressing BMSCs stimulates osteoblast differentiation and new bone formation, but inhibits adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma expression in Nfic(-/-) mice showing an age-related osteoporosis-like phenotype. Finally, NFI-C directly regulates Osterix expression but acts downstream of the bone morphogenetic protein-2-Runx2 pathway. These results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. Therefore, regulation of NFI-C expression in BMSCs could be a novel therapeutic approach for treating agerelated osteoporosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据