期刊
STEM CELLS
卷 29, 期 9, 页码 1437-1447出版社
WILEY-BLACKWELL
DOI: 10.1002/stem.687
关键词
Neural stem cell; Neural differentiation; Tissue-specific stem cells; Differentiation; Proliferation
资金
- Munster Graduate Program for Cell Dynamics and Disease (CEDAD)
- Marie Curie Fellowship
- University of Munster Medical School [SC120901, SC411003]
- Interdisciplinary Center for Clinical Research (IZKF) Munster [SchwJ3/001/11]
- German Research Foundation [SCHW1392/2-1, SFB629]
- Kompetenznetzwerk Stammzellforschung NRW
- Fonds der Chemischen Industrie
- Fritz Thyssen Foundation [Az. 10.10.2.152]
- German-Israeli Foundation (GIF) for Scientific Research and Development [G-2226-2034.1/2009]
- EU
Several studies over the last couple of years have delivered insights into the mechanisms that drive neuronal differentiation. However, the mechanisms that ensure the maintenance of stemness characteristics in neural stem cells over several rounds of cell divisions are still largely unknown. Here, we provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C zeta. Through this interaction, TRIM32 is retained in the cytoplasm. However, during differentiation, this interaction is abrogated and TRIM32 translocates to the nucleus to initiate neuronal differentiation by targeting c-Myc for proteasomal degradation. STEM CELLS 2011;29:1437-1447
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据