期刊
STEM CELLS
卷 27, 期 6, 页码 1463-1468出版社
ALPHAMED PRESS
DOI: 10.1002/stem.63
关键词
Bone marrow transplantation; Fibroblasts; Cancer; Gastrointestinal neoplasms; Stromal cells
资金
- Gastroenterological Society of Australia
- Royal Australasian College of Physicians Cottrell Fellowship
This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia. STEM CELLS 2009;27:1463-1468
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