期刊
STEM CELL REVIEWS AND REPORTS
卷 11, 期 1, 页码 180-193出版社
SPRINGER
DOI: 10.1007/s12015-014-9553-9
关键词
Stem cell; Spinal Cord Injury; Transplantation; Regeneration; Dog; Large Animal Model; Translation
资金
- Fundacao para a Ciencia e a Tecnologia, Ministerio da Educacao e Ciencia, Portugal [SFRH/BD/64871/2009]
- Medical Research Council, UK [22358]
- Medical Research Council [G0802547] Funding Source: researchfish
- MRC [G0802547] Funding Source: UKRI
The use of cell transplantation for spinal cord injury is a rapidly evolving field in regenerative medicine. Numerous animal models are currently being used. However, translation to human patients is still a challenging step. Dogs are of increasing importance as a translational model for human disease since there is a greater awareness of the need to increase the quality of preclinical data. The use of dogs ultimately brings benefit to both human and veterinary medicine. In this review we analyze experimental and clinical studies using cell transplantation for canine spinal cord injury. Overall, in experimental studies, transplantation groups showed improvement over control groups. Improvements were measured at the functional, electrophysiological, histological, RNA and protein levels. Most clinical studies support beneficial effects of cell transplantation despite the fact that methodological limitations preclude definitive conclusions. However, the mechanisms of action and underlying the behavior of transplanted cells in the injured spinal cord remain unclear. Overall, we conclude here that stem cell interventions are a promising avenue for the treatment of spinal cord injury. Canines are a promising model that may help bridge the gap between translational research and human clinical trials.
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