期刊
STEM CELL REVIEWS AND REPORTS
卷 5, 期 3, 页码 266-277出版社
SPRINGER
DOI: 10.1007/s12015-009-9083-z
关键词
Cord blood; Mesenchymal stromal cell; Osteoblast; Bone defect
Bone regeneration is one of the best investigated pathways in mesenchymal stromal cell (MSC) biology. Therfore strong efforts have been made to introduce tissue engineering and cell therapeutics as an alternative treatement option for patients with bone defects. This review of the literature gives an overview of MSC biology aiming for clinical application including advantages but also specific challenges and problems which are associated with cord blood derived stromal cell (CB-MSC) as a source for bone regeneration. The use of postnatal CB-MSC is ethically uncomplicated and requires no invasive harvesting procedure. Moreover, most data document a high osteogenic potential of CB-MCS and also low immunoreactivity compared with other MSC types. The expression profile of CB-MSC during osteogenic differentiation shows similarities to that of other MSC types. Within the umbilical cord different MSC types have been characterized which are potent to differentiate into osteoblasts. In contrast to a large number of in vitro investigations there are only few in vivo studies avaiable so far.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据