Cardiac stem cell niches

The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches represent specialized microdomains where the quiescent and activated state of resident stem cells is regulated. Alterations in niche function with aging and cardiac diseases result in abnormal sites of cardiomyogenesis and inadequate myocyte formation. The relevance of Notch1 signaling, gap-junction formation, HIF-1 alpha and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed. (C) 2014 The Authors. Published by Elsevier B.V.