Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies

Within-person variability in measured values of multiple risk factors call bias their associations with disease. The multivariate regression calibration (RC) approach call correct for such measurement error and has been applied to Studies in which true Values or independent repeat measurements of the risk factors are observed oil a subsample. We extend the multivariate RC techniques to a meta-analysis framework where Multiple studies provide independent repeat measurements and information oil disease outcome. We consider the cases where sonic or all studies have repeat measurements, and compare study-specific, averaged and empirical Bayes estimates of RC parameters. Additionally, we allow for binary covariates (e.g. smoking status) and for uncertainty and time trends in the measurement error corrections. Our methods are illustrated using a subset of individual participant data from prospective long-term studies ill the Fibrinogen Studies Collaboration to assess file relationship between usual levels of plasma fibrinogen and the risk of coronary heart disease, allowing for measurement error in plasma fibrinogen and several confounders. Copyright (C) 2009 John Wiley & Soils, Ltd.