期刊
STATISTICS IN MEDICINE
卷 27, 期 10, 页码 1667-1678出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/sim.3203
关键词
biomarkers; correlated measurements; diagnostic tests; interim looks and early stopping; correlated U-statistics
类别
资金
- Intramural NIH HHS [NIH0014367067, Z01 HD008761-05] Funding Source: Medline
We consider evaluation and comparison of the diagnostic accuracy of biomarkers with continuous test outcomes, possibly correlated due to repeated measurements. We develop nonparametric group sequential testing procedures to evaluate and compare the area of biomarkers under their receiver operating characteristic curves, with either independent or paired test outcomes. These procedures rely on the construction of a two-dimensional statistic of Whitehead (Statist. Med. 1999; 18:2271-2286) so that design methods based on Brownian motion can be applied. Copyright (C) 2008 John Wiley & Sons, Ltd.
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