期刊
STATISTICAL METHODS IN MEDICAL RESEARCH
卷 28, 期 10-11, 页码 3112-3122出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0962280218797151
关键词
Analysis of variance; cluster randomised trial; intracluster correlation; model misspecification; stepped wedge
类别
资金
- National Health and Medical Research Council of Australia [1108283]
- National Health and Medical Research Council of Australia [1108283] Funding Source: NHMRC
Multiple-period cluster randomised trials, such as stepped wedge or cluster cross-over trials, are being conducted with increasing frequency. In the design and analysis of these trials, it is necessary to specify the form of the within-cluster correlation structure, and a common assumption is that the correlation between the outcomes of any pair of subjects within a cluster is identical. More complex models that allow for correlations within a cluster to decay over time have recently been suggested. However, most software packages cannot fit these models. As a result, practitioners may choose a simpler model. We analytically examine the impact of incorrectly omitting a decay in correlation on the variance of the treatment effect estimator and show that misspecification of the within-cluster correlation structure can lead to incorrect conclusions regarding estimated treatment effects for stepped wedge and cluster crossover trials.
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