期刊
STATISTICAL METHODS IN MEDICAL RESEARCH
卷 23, 期 1, 页码 42-59出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0962280212445834
关键词
Mixed models; random effects; shared parameters; marginal models; conditional models; latent variables
类别
资金
- IAP research Network of the Belgian Government (Belgian Science Policy) [P6/03]
- NIH [P01 CA142538, R37AI031789, R01 CA085848]
Longitudinal experiments often involve multiple outcomes measured repeatedly within a set of study participants. While many questions can be answered by modeling the various outcomes separately, some questions can only be answered in a joint analysis of all of them. In this article, we will present a review of the many approaches proposed in the statistical literature. Four main model families will be presented, discussed and compared. Focus will be on presenting advantages and disadvantages of the different models rather than on the mathematical or computational details.
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